PhD Position - Max Planck Institute for Heart and Lung Research

Description & Details:

The Max Planck Institute for Heart and Lung Research in Bad Nauheim (near Frankfurt, Germany), Department of Developmental Genetics (Prof. Dr. Didier Stainier) is looking for a highly motivated Ph.D. candidate to investigate the molecular fingerprint of cardiac fibrosis development and the establishment of zebrafish as a screening platform to identify novel therapeutic pathways.

Cardiac fibrosis (CF) is a common pathophysiological condition associated with many cardiovascular complications. CF is characterised by excessive collagen deposition in the extracellular matrix, caused by increased differentiation of cardiac fibroblasts into myofibroblasts, as a response to tissue stress. Despite its clinical importance, the mechanisms underlying the onset and progression of CF remain poorly understood. As available animal models have significant shortcomings, we have developed the adult zebrafish heart as a superior platform to study CF and to enable rapid testing of compounds to prevent CF progression. The aim of this work is to investigate the molecular fingerprint of fibrosis development by combining three newly established zebrafish CF models with a multi-omics approach and validating our findings in human samples. In addition, this system will be used to evaluate the potential of pharmacological modulators in slowing down/reversing the progression of CF.

Qualifications and Responsibilities:

We are looking for a highly motivated and qualified student to join our research team. To be eligible, candidates must hold or expect to obtain a Master's degree (M.Sc. or equivalent) before starting. A Master's degree in a relevant field such as biology, biochemistry or a related discipline with a strong focus on molecular biology, cell biology or biochemistry is preferred. Previous experience working with zebrafish is an advantage but not required. We encourage applicants with a strong academic background and a passion for research to apply.

About the Employer:

The Max Planck Institute for Heart and Lung Research in Bad Nauheim is an interdisciplinary research institution with international flair. Our researchers have the opportunity to work on various model systems by making use of the latest cutting-edge technologies. Researchers are supported by state-of-the-art core facilities which offer services in next-generation sequencing, proteomics, bioinformatics, cytometry, microscopy, and small animal imaging. The Max Planck Society strives for gender and diversity equality; we welcome applications from all backgrounds. Furthermore, the Max Planck Society is committed to increasing the number of individuals with disabilities in its workforce and therefore encourages applications from such qualified individuals.

To Apply:

Applications will be evaluated upon submission. The expected start date is flexible (from February 2025 at the earliest). To apply, please submit the names and contact information for 2-3 references, a CV, a short (1 page) letter of motivation of your research experience and interests no later than 15 January 2025 via our online application portal (https://recruitingapp-5462.de.umantis.com/VacanciesIntraxData/353/Application/New/2). For informal inquiries, please contact Dr. Marco Tarasco (Marco.Tarasco@mpi-bn.mpg.de).